From Xanax to cocaine, drugs or counterfeit pills purchased in nonmedical settings may contain life-threatening amounts of fentanyl. Many addiction experts say the supply of street fentanyl in the U.S. is drying up — a win in the fight against overdose deaths that many experts once viewed as unachievable. And for fentanyl users receiving treatment for their addiction, doctors must prescribe higher doses of medications like suboxone and methadone to control their withdrawals. Opioids include prescription painkillers (such as oxycodone) and illegal drugs (such as heroin and fentanyl). Outside of medical settings, fentanyl appears as a white powder. It is also used to cut drugs, meaning it’s mixed with other substances to make the quantity of the secondary substance stretch.

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While there are fentanyl patches that can be placed on the skin for pain management, this is not the formulation that’s cut into other substances. Fentanyl is a synthetic opioid that is about 50 times as potent as heroin. People use fentanyl because it is cheap to manufacture and a small amount goes a long way. Many individuals consume fentanyl without knowledge while others use it intentionally because of its potency.
Medical Uses
If you suspect someone is overdosing on fentanyl, call emergency services immediately. If available, administer naloxone, a medication that can rapidly reverse opioid overdose. People taking a daily prescribed dose will become dependent on the drug and will have withdrawal symptoms if they stop it. This is not an addiction but instead a physiological response.
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But as Lopez has detailed time and again, cracking down on supply — as the Portman bill would — doesn’t do anything to address demand or treatment, which many experts name as the bigger issues. Even through the narrow lens of cutting the drug supply, the sellers have already proven adept at adapting to new circumstances. Now that shipments from China have come under suspicion, the sellers told the investigators that they preferred to ship through Europe. Even as the US worked with China to crack down on one fentanyl compound, the sellers simply tweaked their formula and offered to sell a new version in another email included in the report.
Responding To An Overdose
This can decrease the amount of oxygen that reaches the brain, a condition called hypoxia. Hypoxia can lead to a coma, permanent brain damage, and even death. Because the drug is less expensive than other opioids, people making it illegally commonly mix it into drugs such as heroin, cocaine, or methamphetamines. If you buy drugs illegally, there is a chance fentanyl can be in them. People sell illegal fentanyl as a powder, dropped onto blotter paper, put in eye droppers and nasal sprays, or as pills that look like other prescription opioids. Despite these programs, the internet has made buying almost anything online an option.
US Drug Overdose Deaths Involving Cocaine, By Opioid Involvement, 1999-2023
You can buy naloxone over the counter from a local pharmacy, and you do not need training or authorization to use it. Some people take fentanyl illegally by separating it from skin patches and injecting it. While it’s safe for your doctor to give you fentanyl in a medical setting, some people abuse it, which can lead to an overdose. With the popularity of drug dealers mixing fentanyl into other drugs, fentanyl test strips can help people who use drugs identify whether what they are taking contains fentanyl or not. These small, paper strips can be obtained at needle-exchange sites, are easy to use and only take minutes to interpret. To help reduce the risk of fentanyl abuse, addiction and overdose, the Food and Drug Administration requires fentanyl prescriptions to be closely monitored to ensure the benefits outweigh the risks.
- Fentanyl is 100 times stronger than morphine and 50 times stronger than heroin (DEA, n.d.).
- Fentanyl can last for a few hours when taken orally or when snorted, smoked, or injected.
- According to the CDC, the rate of fentanyl overdoses in 2020 was 18 times higher than in 2013.
- For those taking fentanyl in nonmedical settings, there is no medical team available to monitor someone’s breathing rate in real time to ensure their safety.
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There are hurdles, including international treaties and the readiness or willingness of other countries to implement the same standards. The investigators didn’t actually execute a purchase, because even a small amount of fentanyl can be lethal. But they learned how simple it was to buy these powerful opioids online and how brash the sellers were. “Because fentanyl is so powerful, patients are having greater physical withdrawals,” Ward said.
The effects of fentanyl (and all opioids) can be blocked and reversed with the use of Narcan. Anyone can purchase Narcan over the counter, and there are places that give it away for free (see below). In recent years the drug supply has become overrun with illicitly manufactured synthetic fentanyl, which can be manufactured very cheaply. The fentanyl we see in the US drug supply mostly comes from Mexico and China. Fentanyl test strips can identify the presence of fentanyl in unregulated drugs.
- Some opioids come directly from the opium poppy plant, but manufacturers make fentanyl in a lab and reproduce the chemical structure.
- While some opioids come directly from the plant, fentanyl is made in a lab by scientists using the same chemical structure.
- Fentanyl has medical uses, primarily to control severe pain after surgery and in advanced-stage cancer treatment.
- As little as 2 milligrams or less may cause death, which is about the size of a few grains of salt.
- The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland.
- To get extremely potent opioids, users turn to the dark web—and sometimes, Google.
It is typically used for managing severe pain, particularly among cancer patients or those undergoing major surgeries. However, its illicit use has surged in recent years, contributing to the ongoing opioid crisis. Illicit fentanyl related products are described including the different forms it can appear in. The rise in use and overdoses are described as well as some of the reasons for these changes. Implications for overdose prevention and initiating treatment with medications for opioid use disorder are described. In 2020, over 80% of the fentanyl police confiscated with in tablet form.
After you talk with your doctor, you will sign a form acknowledging that you understand the risks of using fentanyl and that you will follow your doctor’s instructions to use the medication safely. Your doctor will give you more information about the program and how to get your medication and will answer any questions you have about the program and your treatment with fentanyl. You can’t overdose by touching an item containing fentanyl. Some medical fentanyl is delivered through skin patches, but it is absorbed slowly over the course of hours.

Treating Fentanyl Addiction
And so far, the Trump administration’s response to the opioid crisis — a regular talking point for the president on the campaign trail — has been severely lacking in those other, arguably more pressing areas. Portman and a bipartisan group of senators have actually introduced legislation to require the Postal Service to collect this electronic data. It is also an idea that President Trump has at times endorsed.
Talk to your doctor about how well the medication is working and whether you are experiencing any side effects so that your doctor can decide whether your dose should be adjusted. Tell your doctor if you feel that your pain is not controlled or if your pain increases, becomes worse, or if you have new pain or an increased sensitivity to pain during your treatment with oxycodone. Do not take more of it or take it more often than prescribed by your doctor.